網路內科繼續教育
有效期間:民國 90年04月16日 90年04月30日

    Case Discussion

Brief History

      This 37 y/o man was admitted because of substernal pain for 7 days and fever for 3 days.

      He was rather well in the past and was a chicken dealer at a traditional market. One week before admission he developed a substernal chest pain which was dull, persistent and was aggravated by inspiration. A low-grade fever and progressive exertional dyspnea were also noted 3 days prior to admission. There was no cough, vomiting, diarrhea, abdominal pain, or skin rash. He was admitted to a local hospital where hypoxemia (PaO2 56 mm Hg on room air) and leukocytosis with left shift were found. He was transferred to our ER due to persisted fever on Oct.13, 2000.

      On examination, his consciousness was clear and blood pressure was 93/56 mm Hg, pulse rate 95/min, and body temperature 37.2 °C. Persisted local tenderness over substernum area was complained of. The initial chest radiograph showed slightly widened vascular pedicle but no definite abnormality over lung parenchyma. High fever (38.9 °C) and dyspnea occurred on the second hospital day and non-rebreathing bag was required to maintain his SpO2 > 90%. The chest radiograph (Fig. 1) showed widening of the mediastinal shadow, especially on the right side. Yellowish, turbid pleural effusion was aspirated from bilateral pleural cavities. He was transferred to the ICU on Oct. 16.

Lab. Data
[ CBC+PLT ]

  WBC  RBC HB  HCT MCV MCH  MCHC PLT
日期
(時間)
 K/μL M/μL g/dL

%

 fL pg  g/dL K/μL
0891013
(2158)
10.39 4.13 12.7 37.8 91.5 30.8 33.6 165.0
0891016
(1234)
18.52 3.92 12.1 36.0 91.8 30.9 33.6 188.0
0891027
(0517)
23.79 4.11 12.2 37.5 91.2 29.7 32.5 596.0
0891106
(0456)
11.25 3.65 10.9 32.8 89.9 29.9 33.2 382.0
0891112
(0834)
4.61 4.65 13.7 41.0 88.2 29.5 33.4 166.0

  Blast Promyl. Myelo. Meta Band Seg Eos. Baso. Mono.
日期
(時間)

   %

% % % % % % % %
0891013 (2158) 0.0 0.0 0.0 0.0 93.5 0.0 0.2 2.9  
0891016 (1234) 0.0 0.0 0.0 0.0 88.3 0.4 0.0 5.1  

  Lym. Aty.Lym.
日期 (時間) % %
0891013 (2158) 3.4 0.0
0891016 (1234) 5.9 0.0

  PT  PT Cont PTT PTT Cont   INR
日期 (時間) sec sec sec sec  
0891013 (2212) 13.6 12.4 47.9 37.4 1.1
0891016 (1247) 14.4 11.9 56.4 37.7 1.2

 [ Biochemistry ]

  UN CRE Na K Cl T-BIL Ca
  mg/dl mg/dl mmole/l mmole/l mmole/l mg/dl mmole/l
0891013 14.0 1.1 139.0 3.0 104.0 0.6 2.09
0891016 8.0 0.9 138.0 4.6 106.0 1.1 2.02
0891116 7.0 0.4 131.0 4.2 107.0   

  Mg P AST   Lactic Acid CK CK-MB
  mmole/l mg/dl U/l mmole/l U/l U/l
0891013     29.0   614.0 11.0
0891016 1.0 2.6 18.0 1.5 164.0 3.0
0891116     24.0      

[ABG] pH PaCO2 PaO2 HCO3 BE  
891013 7.484 31.5 56.1 23.0 0.3 room air
891016 7.38 34.1 57.1 20.3 -3.5 non-rebreathing mask
891029 7.47 38.5 69.0 27.6 4.2 nasal canula 3L/min   
       

 Course and Treatment 

He was intubated on Oct 17 due to hypoxemia respiratory failure. The emergent CT of chest showed abscess over retroesophageal space and bilateral mediastinal pleurae with gas formation (Fig 2 ,3). Surgical intervention with debridement and drainage was performed on Oct.18. The culture of the drained pus grew Group C streptococcus and viridan streptococcus which were sensitive to penicillin G. Unfortunately, his fever persisted after operation and antibiotic was shifted to Timentin. The follow-up CT of the chest on Oct. 26 still revealed fluid accumulation over mediastinal space. He underwent a second debridement and decortication of pleura, as well as esophagostomy, gastrostomy, and jejunostomy. During the procedure, esophageal perforation was suspected at upper thoracic portion. Culture o the pus still yielded Viridans streptococcus. With strong antibiotic therapy and supportive care, his condition improved gradually and was extubation on Oct. 27. The follow-up CxR (Fig. 4) and chest CT (Fig. 5) revealed improvement of the mediastinal lesions.

    此病患因高燒、胸痛而入院。胸部X光顯示縱膈腔陰影(mediastinal shadow)變寬,且有惡化及擴大之傾向。兩側助膜積液呈現混濁環之外觀及exudate 之生化表現。這些臨床表徵應聯想到縱膈腔發炎(mediastinitis)。急性縱膈腔炎常見於食道穿孔,食道破裂,口腔膿瘍,深頸部發炎及開胸手術後等之併發症。在酗酒及意識不清之病患,有時食道穿孔也可能出現在沒有嚴重嘔吐之病患。縱膈腔發炎以往之致死率相當高,目前由於提早手術引流清創之實施及抗生素之進步,治療率已有提昇。診斷以胸部及頸部之電腦斷層攝影為主。

    食道穿孔或破裂目前以外力造成者居多(如插氣管內管或食道鏡)。本病人病史上無嚴重嘔吐,但產生自發性食道穿孔,且位於中上位食道,較為罕見。此類病患有時需要多次之外科手術引流及長期抗生素使用。

繼續教育考題
1.
(A)
Which of the following descriptions is WRONG for esophageal perforation or rupture?
AThe most common cause nowadays is spontaneous rupture
BCan occur as a complication of esophagoscopy or the insertion of a S-B tube
CThe perforation site of Boerhaave's syndrome is often located in the lower third of esophagus
DPatients often develop fever and a chest pain that is aggravated by inspiration
2.
(C)
Which of the following statements is WRONG regarding mediastinitis?
AMost cases of acute mediastinitis are either due to esophageal perforation or occur after median sternotomy for thoracic surgery.
BMost patients present with a history that extends over a couple of days with gradual worsening pain.
CThe patients typically are elderly females
DThe patient may develop edema of the neck and face, with occasional crepitus over anterior chest
3.
(D)
Which of the following descriptions of esophageal rupture or perforation is WRONG?
ADelayed diagnosis is common
BElevated amylase level in the pleural fluid may be helpful for the diagnosis
CCxR may show evidence of pneumomesiastinum or hydropneumothorax
DPleural effusions and lower lobe consolidation are not common
4.
(D)
Which of the following descriptions of chronic mediastinitis is true?
AMost cases are due to tuberculosis or histoplasmosis, but sarcoidosis, silicosis, and other fungal diseases are at times causative
BPatients with granulomatous mediastinitis are usually asymptomatic
CThose with fibrosing mediastinitis usually have signs of compression of some mediastinal structure such as the superior vena cava or large airways, phrenic or recurrent laryngeal nerve paralysis
DAll of the above
5.
(C)
Which of the following descriptions of the pathogen of mediastinitis is WRONG?
AThis is often a mixed infection, with obligate anaerobes usually outnumber facultative organisms by 10:1
BStreptococcus species are the most common facultative organisms
CClostridium species are the most common strict aerobes.
DOther organisms implicated include Pseudomonas aeruginosa, and species of Fusobacterium, Peptostreptococcus, and Staphylococcus.
6.
(D)
The criteria for the diagnosis of acute descending mediastinitis include the following:
AClinical evidence of severe oropharyngeal infection
BCharacteristic roentgenographic features of mediastinitis
CDocumentation of mediastinal infection at operation
DAll of the above
7.
(D)
When should mediastinitis be considered in the differential diagnosis?
AIn any patient with severe chest pain after a dental abscess
BIn patients with chest discomfort after an upper respiratory infection.
CIn a patient with bilateral empyema
DAll of the above
8.
(D)
What factors may predispose a patient to mediastinitis?
AThe presence of diabetes mellitus
BAn immunocompromised state
CAlcoholism and severe vomiting
DAll of the above
9.
(A)
What is the diagnostic test of choice for mediastinitis?
ACT scan or MRI of the chest
BMediastoscopy
CChest sonography
DNeck sonography
10.
(B)
Which description is WRONG  regarding the management of mediastinitis?
APatients should be referred to a tertiary institution whenever the resources at the initial hospital are not sufficient to manage their care.
BThe mortality rate in most series is about 10%
CPatients may need prolonged antibiotic therapy
DRepeated CT scans are essential to follow the progress of therapy

答案解說

答案解說:

  1. (A) Spontaneous esophageal rupture is becoming rare nowadays. It more commonly develop as a complication of esophagoscopy, the insertion of a S-B tube, esophageal intubation, or sternotomy for thoracic surgery.
  2. (C) The patients typically are young or middle-aged males. The male: female ratio is 6:1
  3. (D) Pleural effusion and lower lobe consolidation are not unusual.
  4. (D) All descriptions are correct.
  5. (C) Bacteroides species are the most common strict aerobes
  6. (D) All descriptions are correct.
  7. (D) All descriptions are correct.
  8. (D) All descriptions are correct.
  9. (A) Chest CT is the diagnostic test of choice for mediastinitis. CT scans may demonstrate abnormalities when the CXRs still appear normal. Abscesses and soft tissue swelling usually are clearly seen.
  10. (B) Treatment includes immediate drainage, debridement, and parenteral antibiotic therapy, but the mortality still exceeds 20 percent. Mortality varies from 19-47% in most series. In the presence of comorbid conditions, mortality for patients first seen with established infections may be as high as 67%.

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